- If you have an allergy to atovaquone, proguanil, or any other part of atovaquone and proguanil.
- If you are allergic to atovaquone and proguanil; any part of atovaquone and proguanil; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
- If you have kidney problems.
- If you are taking any of these drugs: Rifabutin or rifampin.
This is not a list of all drugs or health problems that interact with atovaquone and proguanil.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take atovaquone and proguanil with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
Side effects requiring immediate medical attention
Along with its needed effects, atovaquone/proguanil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur while taking atovaquone / proguanil:
Incidence not known
- Blistering, peeling, loosening of skin
- difficulty swallowing
- fast heartbeat
- hives or welts
- increased sensitivity of skin to sunlight
- itching, redness or other discoloration of skin
- joint or muscle pain
- large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs
- loss of bladder control
- muscle spasm or jerking of all extremities
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- red, irritated eyes
- red skin lesions, often with a purple center
- seeing, hearing, or feeling things that are not there
- severe mental changes
- severe sunburn
- shortness of breath
- skin rash
- sores, ulcers or white spots in mouth or on lips
- sudden loss of consciousness
- tightness in chest
- unusual tiredness or weakness